Identifying differentially expressed genes in unreplicated multiple-treatment microarray timecourse experiments
نویسندگان
چکیده
منابع مشابه
Identifying differentially expressed genes in unreplicated multiple-treatment microarray timecourse experiments
Microarray technology has become widespread as a means to investigate gene function and metabolic pathways in an organism. A common experiment involves probing, at each of several time points, the gene expression of experimental units subjected to different treatments. Due to the high cost of microarrays, such experiments may be performed without replication and therefore provide a gene express...
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A major goal of microarray experiments is to determine which genes are differentially expressed between samples. Differential expression has been assessed by taking ratios of expression levels of different samples at a spot on the array and flagging spots (genes) where the magnitude of the fold difference exceeds some threshold. More recent work has attempted to incorporate the fact that the va...
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High throughput technologies, such as gene expression arrays and protein mass spectrometry, allow one to simultaneously evaluate thousands of potential biomarkers that could distinguish different tissue types. Of particular interest here is distinguishing between cancerous and normal organ tissues. We consider statistical methods to rank genes (or proteins) in regards to differential expression...
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ژورنال
عنوان ژورنال: Computational Statistics & Data Analysis
سال: 2006
ISSN: 0167-9473
DOI: 10.1016/j.csda.2004.09.004